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Critical role of extracellular signal-regulated kinase phosphorylation on menadione (vitamin K3) induced growth inhibition

(b) Bifidobacterium longum can downregulate inflammatory cytokines and inhibit NF- B pathway to regulate the intestinal immune system and protect intestinal epithelial cells

Moreover, elderly pDCs are less capable of stimulating CD8 + T cells to produce perforin and granzyme, which are crucial for cytotoxic activity, and they are less efficient in promoting IFN- secretion by CD4 + and CD8 + T cells [258]

Among the 22 FRGs, high expression of 6 FRGs can lead to poor prognosis in LIHC patients, namely SLC7A11, TFRC, CISD1 , CS, FANCD2 , and RPL8

10.1016/s0022-510x(99)00203-8 159 Marti-SanchezL.Ortigoza-EscobarJ