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Upon cellular uptake of Cu-Cys nanoparticles by tumor cells, they first react with local GSH, inducing GSH depletion and reducing Cu2+ to Cu+

One syndrome, mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS), is associated with mutations in mitochondrial DNA (Bousser and Welch, 2005)

Regarding the assessment of long-lasting impacts, MSCs-administered mice revealed that 60%80% of the samples became pregnant in the second cycle of breeding