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TGF- is activated through interactions with glycoprotein A repetitions predominant (GARP), integrins, proteases, and other TGF--binding proteins, enabling its subsequent binding to the TGF- receptor family (TR) [36]

Histopathological changes of vestibulocochlear nerve tissue was defined as presence of degenerated myelinated nerve fibers, dilatation of the vessel, congestion and collagen deposition

Similarly, GABA, dopamine, and other neurotransmitters are significantly influenced by gut function

IL-1 and IL-6 are key pro-inflammatory cytokines that trigger local inflammatory responses and tissue damage, while IL-4 and IL-10 are major anti-inflammatory cytokines that inhibit the production of pro-inflammatory factors and promote the resolution of inflammation ( NF- B pathway components in the reproductive organs compared with other tissues, a hypothesis that warrants further investigation in future mechanistic studies

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