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Other growth factors such as bone morphogenetic proteins (BMPs) have received FDA approval for specific indications and may represent more appropriate therapeutic choices for conditions where approved therapies are available and indicated

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The endothelial damage, release of TF and intravascular TF, and elevated proinflammatory cytokines trigger immunothrombosis in the pulmonary microvasculature, yielding microclots [15]

Practical takeaway: FOXO4-DRI's senolytic mechanism is well-established in cell culture and animal models