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JCI Insight 8(11):e166001 Liang Y et al (2022) Inhibition of the IRE1/JNK pathway in renal tubular epithelial cells attenuates ferroptosis in acute kidney injury

Scientific Overview Dihexa binds to hepatocyte growth factor (HGF) with high affinity and potentiates its activity at the c-Met receptor in research settings

Increased bile acid concentrations indicate a dysfunction of the liver (or abnormalities of the liver vessels), even before the onset of jaundice

!Immunosuppressants - c-Met signaling plays roles in immune function and tissue repair

They are not just metabolic byproducts but also act as important second messengers that regulate biochemical pathways, transcriptional programs, and the epigenetic states necessary for cellular functions, including cell proliferation and differentiation [5, 6]