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Most of these are mild

doi: 10.1038/cr.2009.117

For example, a randomized controlled trial indicated that patients receiving SERMs experienced a marked improvement in pigmentation scores after 12 weeks of treatment

In contrast, when exposed to erastin, a typical ferroptosis inducer, GCLM and GCLC expression remained relatively constant, while SLC7A11 and NQO1 were notably elevated (Fig

Many of the studies evaluating different combinations of antioxidants, however, have used different methodologies, impeding replication.71 There is insufficient clinical evidence to recommend the use of dietary supplements in the management of skin aging, and some authors urge caution when it comes to recommending vitamins or dietary supplements to well-nourished individuals.72 Promising results have been observed with extracts from plants such as Aloe vera, Citrus paradisi, Rosmarinus officinalis, Cyclopia intermedia, and Hydrangea serrata,73 but clinical evidence is lacking