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Meanwhile, those at risk for certain cancers are more interested in lowering their levels (5, 7, 8)

Metabolic processes of transformed molecules such as GPX4 and PUFAs protect against cellular lipid peroxidation processes and indirectly induce ferroptosis (117)

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To overcome these problems, various halogenated derivatives (e.g., chlorinated or boronated PBN), alkylated derivatives having a lipophilic tail (e.g., those with dodecyl chains), bifunctional derivatives (e.g., GS-PBN, Mito-DEPMPO, 5-ChEPMPO, DECPO, and 4-HMDEPMPO), conjugates with drugs or targeting molecules (such as PEG or heparin, that both can cross the BBB), dimers, and cyclodextrin polymers have been developed in the last few years (Wang et al., 2021

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