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Similarly, recruitment of participants with severe hepatic impairment into the hepatic impairment study was challenging and, despite a third study site being added and the recruitment period being prolonged, it was not possible to complete recruitment of seven participants into the severe hepatic impairment group

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Anti-Inflammatory and Cytokine Modulation Research: Across multiple rat inflammatory models (carrageenan-induced paw edema, colitis, arthritis), the blend synergistically reduced pro-inflammatory cytokines (TNF-, IL-6, IL-1), inhibited leukocyte infiltration, and accelerated resolution of inflammation while minimizing fibrosis and scar formation

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Cosmetic safety data from extended-use studies supports continuous application at the concentrations listed above