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Collectively, our studies provide compelling new evidence that mTOR and Erk1/2 are being acutely regulated by dietary MR to provide regulatory input to the hepatic ISR in the hours after initiation of the diet

PMID: 29801486

When exposed to EVs carrying functional mtDNA, recipient cells can restore defective mitochondrial function, significantly enhancing energy production capabilities and providing critical molecular support for cancer proliferation and metastasis

Recommendations for future research and clinical practice Although the number of studies was small, we could generate synthesis which can direct further research towards making well-designed, high-quality, RCTs investigating the different doses of VitE, as our results showed a promising beneficial effect of VitE in G6PD deficiency patients, especially with chronic hemolysis

It has been shown to reset pathological gene expression to healthier states, which may counteract age-related dysregulation of biochemical pathways and support neuronal survival and function 11