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This lipid accumulation impairs DC-T cell interactions, whereas XBP1 silencing in DCs enhances their antitumor functionality and immunostimulatory dendritic cell activity [84]

These neuronal activation patterns are attenuated or absent in RAMP1/RAMP3 knockout animals, further implicating AMYR and AMYR as the functional receptors mediating these central effects

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4.3 Microglia modulation Neuropsychiatric disorders are frequently characterized by increased OS and inflammatory responses, with abnormal activation and dysfunction of microglia playing a significant role (Lehmann et al., 2019)