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These beneficial effects are attributed to patchoulene epoxides ability to regulate colonic microbiota and metabolic processes

IDH1 is the cytosolic enzyme that catalyses the oxidative decarboxylation of isocitrate to -KetoGlutarate (-KG) and IDH1-mutated cells catalyse the reduction of -KG to 2HG, which drives tumorigenesis and is thus defined as oncometabolite [88, 89]

Redox cycling of catechol estrogens generating apurinic/apyrimidinic sites and 8-oxo-deoxyguanosine via reactive oxygen species differentiates equine and human estrogens

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Cells of origin in the embryonic nerve roots for NF1-associated plexiform neurofibroma