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Methylfolate is required in the activation of tetrahydrobiopterin (i.e., BH4), which is a necessary cofactor for both tryptophan hydroxylase and tyrosine hydroxylase, enzymes required in the synthesis of serotonin and norepinephrine/dopamine, respectively (Figure 1)

Hence, certain drugs that regulate the excitatory amino acids have been considered as an important aspect of treatment

Several studies have examined whether chromium picolinate may be useful in this capacity

However, the absence of documented interactions does not automatically mean the combination is appropriate for everyone

NA: Writing original draft