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This effect is likely to be mediated through several pathways: a) Upregulation of antioxidant enzymes: The significant increase in catalase levels observed in the IF group suggests that IF enhances endogenous antioxidant defenses, as catalase is a key enzyme in detoxifying hydrogen peroxide and mitigating oxidative stress

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Besides, the multi-target property and favorable biocompatibility makes TCM a viable option for combining with chemotherapy to enhance treatment outcomes while reducing side effects [27,28,29]

The emergence of Anifrolumab underscores the potential for targeting type-I IFN in the treatment of SLE