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The antagonism is possibly due to increased glutathione conjugation

It is responsible for most of the antioxidant and detoxifying functions of Glutathione

Downregulation of ETV5 reduces insulin secretion possibly through reduced expression of exocytotic genes

That study revealed that ferrylHb but not Hb or metHb induce active IL-1 production in LPS-primed macrophages in an NLRP3-dependent manner ( Hemorrhage-Associated Macrophage Subsets Besides the two extreme canonical macrophage phenotypes, the pro-inflammatory M1 and the anti-inflammatory M2, many other specific and distinct macrophage subsets exist (103)