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The progressive degeneration of neuronal cells that accompanies the decline of memory and other cognitive functions in subjects with Alzheimers disease is associated with an intracellular aggregation of Tau fibrils, an extra-neuronal accumulation of b-amyloid peptides into senile plaques, and an oxidation-reduction (redox) imbalance of complex etiology

The zeta potential of AgNPs determines their colloidal stability, with highly positive or negative values preventing aggregation (Blteky et al., 2019)

Furthermore, the mechanism of APP in serum antioxidant properties was explored.The serum contains a certain amount of basal nitrite /nitrate and ROS, as well as enzymatic and non-enzymatic antioxidant systems to maintain a state of redox homeostasis 35,36