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We found that community-dwelling older physically disabled women with metabolically significant vitamin B12 deficiency had a risk of depression that was more than twice as high as that of women without vitamin B12 deficiency

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The authors explicitly stated that the study was "not intended to provide guidance on the sublingual dosing of semaglutide in humans." Extrapolating from a rat study on a different peptide to human use of tirzepatide drops involves multiple leaps of scientific faith that responsible review cannot endorse