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However, rather than directly affecting FAO, SCAP deficiency suppressed regulation of genes involved in sterol biosynthesis, including critical enzymes such as 3-hydroxy-3-methylglutaryl coenzyme A reductase

55,56 Its pathogenesis is highly complex, involving the interplay of factors including lipid metabolism disorders, 57 insulin resistance, 10 oxidative stress, 58 immune activation, 13 and gut microbiota dysbiosis

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