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Therefore, some studies have shown that the level of D-serine in the host may be related to neurological diseases, such as Alzheimers disease, cognitive dysfunction, schizophrenia, depression, and addiction (Holeek, 2022)

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For example, DHI, composed of Salvia miltiorrhiza and Carthamus tinctorius in a 3: 1 ratio, can comprehensively alleviate CI/RI in rats by upregulating mitochondrial dynamics-related proteins such as Mfn1, Mfn2, and OPA1 and downregulating apoptosis-related pathway proteins such as Cyt c, Apaf1, Bax, Caspase-3, and Caspase-9 (Du et al., 2023)

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Mechanistically, SCFAs regulate local renal inflammation and ROS via binding to free fatty acid receptors orphan G-protein coupled receptor (GPCR) family, such as GPR43, GPR41, GPR109a, and olfactory receptor 78 (Olfr78), or by acting as histone deacetylase (HDAC) inhibitors [37, 139]