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2.2 Carboplatin Carboplatin (Table 1), a second generation platinum-based chemotherapy drug, has been developed as a result of cisplatin, And it is also known as cis-diamminediyl (1,1-cyclobutanedioic acid) platinum, displaces the two chlorido ligands present in cisplatin with cyclobutanedicarboxylic acid ( 2.3 Nedaplatin Nedaplatin (Table 1) is a second-generation platinum anticancer medication formed through the substitution of two chlorido ligands in cis-platinum with ethanoic acid, having the full name cis-ethanolic acid diammine platinum ( 2.4 Oxaliplatin To prevent cross-resistance to cisplatin and carboplatin combination therapy, the third generation platinum anticancer drug, oxaliplatin, was developed

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Surgi como un anlogo corto sinttico del Epithalamin , un extracto polipeptdico de la glndula pineal, buscando reproducir en una secuencia mnima (el tetrapptido AEDG) la actividad atribuida al preparado original