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Description

J Clin Lipidology 8(3)(May-June Suppl):S17-S29

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Ipamorelins selective GHS-R1a agonism drives GH granule exocytosis from somatotrophs through Gq/11-PLC-IP3-calcium mobilisation , the identical intracellular signalling cascade engaged by non-selective first-generation GH secretagogues and but does so without producing the off-target receptor engagement at pituitary lactotrophs and corticotrophs that drives prolactin and cortisol co-secretion following GHRP-6 and GHRP-2 administration

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Clinical and animal data demonstrate variable yet typically favorable shifts in LH/FSH with GHS, particularly in the context of baseline deficiency or metabolic comorbidities

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