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Anti-MDA5 DM can be life threatening because it is typically associated with rapidly progressive interstitial lung disease (RP-ILD) Rapidly progressive ILD is reported in over 40% of cases and according to research, is the most important factor predicting survival

Man HSJ, Sukumar AN, Ku KH, Dubinsky MK, Subramaniam N, Marsden PA (2018) Gene expression analysis of endothelial cells exposed to shear stress using multiple parallel-plate flow chambers

T cell anergy Following antigen presentation, T cells may become functionally inactivated, in a hyporesponsive state, to induce immune tolerance

The metabolites were identified using a LC 1260/Q-TOF-MSMS 6520 system (Agilent Technologies, Santa Clara, CA, United States) with an Agilent electrospray ionization (ESI) with negative ion mode

Chen WY, Cai LH, Zhang ZH et al