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Atrial fibrillation is associated with the fibrotic remodelling of adipose tissue in the subepicardium of human and sheep atria

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Some studies have shown that when glutathione was given in doses of up to 5g per day, both orally and intravenously, no toxicity was observed

These findings establish the ROS/GSK3/GPX4 axis as a key driver of CO-induced ferroptosis, but how this pathway intersects with other cell-death pathways remains to be clarified