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Furthermore, this systemic exposure was corroborated by significant pathological damage in the sensitive retinal tissue, typically observed as cytotoxic edema

In a recent study, it was shown that patients with asthma who were well controlled with inhaled corticosteroids and long-acting 2 agonists had higher lipid peroxide levels compared with healthy controls [113]

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These evidence, while observed in cardiomyocytes and vascular smooth muscle cell metabolism, is also applicable to explain other important system functional imbalance in the lipotoxic state of high FFAs

Wong, Differential progression of structural and functional alterations in distinct retinal ganglion cell types in a mouse model of glaucoma