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Patients with AHR exhibit marked reductions in gut microbial diversity, particularly depletion of immunomodulatory taxa such as Bifidobacterium and Lactobacillus , which may compromise immune tolerance and exacerbate allergic sensitization ( Lactobacillus johnsonii supplementation reduces immune cell activation in lungs and Th2 cytokine expression (IL-4, IL-5, IL-13, IL-17), suggesting microbiota-targeted strategies for AHR modulation ( 6.2 Gut microbiota and airway remodeling Airway remodelingcharacterized by structural alterations like smooth muscle hypertrophy and subepithelial fibrosisis mechanistically influenced by gut microbiota via systemic inflammatory pathways

[DOI] [PMC free article] [PubMed] [Google Scholar] 237.Veltman C.H.J., Pennings J.L.A., van de Water B., Luijten M

Given that AIP is an inhibitor of PAL, and PAL is a key rate-limiting enzyme in the phenylpropanoid pathway, we investigated the changes in PAL expression

All these unhealthy conditions have been shown, in rigorous scientific studies, to be improved or reversed using a low-carbohydrate diet

Yong SJ