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ROS as signalling molecules: Mechanisms that generate specificity in ROS homeostasis

Wu L, Wang W, Guo M, Fu F, Wang W, Sung T, et al

Pyruvate dehydrogenase complex deficiency results in impaired conversion of pyruvate to acetyl-CoA, reduced production of citrate, and, therefore, impairment of the TCA cycle, leading to severe energy deficits (especially in the CNS)

2012;7:e33853

However, because of the methodological complexity associated to realtime, patiotemporal measurements of formaldehyde in living cells and tissues, these effects have been barely deciphered