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The "minimal initial benefit" group (approximately 5-10% of users) reported limited improvements during treatment making discontinuation effects irrelevant, typically explained by inadequate product quality with degraded or low-concentration GHK-Cu, inappropriate application technique reducing absorption, unrealistic expectations exceeding what any topical can achieve, severe underlying pathology requiring medical intervention beyond cosmetic peptides, or individual non-responsiveness to copper peptide treatment for genetic or physiological reasons

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There is a clear relationship between the sites where more -amyloid is produced and the sites where there is this insulin-glucose receptor relationship, such as the hippocampus, explains professor Francisco Muoz , head of the laboratory and co-author of the study published in the journal Brain Communications