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Alcohol deserves a mention as well

10.1126/science.7624798 70 PengY.MengY.HuS.DingJ.ZhouW

Reported effects from clinical and research-context use Mild flushing or warmth shortly after dosing Mild injection-site redness or irritation Transient headache Brief mild nausea Short LH and FSH rise, usually followed by a return toward baseline Possible testosterone rise after longer exposure in men, if the testes respond to LH Theoretical and chronic-use risks Signal fade with repeated or nonstop exposure