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Recombinant human activated protein C attenuates the inflammatory response in endothelium and monocytes by modulating nuclear factor-B

ABCB1 primarily exports large hydrophobic molecules, whereas ABCC1 and ABCG2 can transport both hydrophobic drugs and larger anionic drug conjugates

neoformans pathogen-associated molecular patterns (PAMPs) through pattern recognition receptors (PRRs) such as Toll-like receptor 2 (TLR2) and C-type lectin receptors (CLRs), initiating phagocytosis and inflammatory cascades (Fu and Drummond, 2020) (Table 1)

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Neural pathways: The vagus nerve is the primary neural connection, with afferent nerve fibers sensing mechanical stimuli, chemical signals, and microbial metabolites within the intestinal lumen, transmitting this information to the nucleus tractus solitarius (NTS), which subsequently projects to higher brain regions, including the amygdala, hippocampus, and prefrontal cortex (Bonaz et al., 2018)