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When delivered topically in stabilized form and activated by visible light, they recognize and cleave damaged DNA sequences in skin cells

Halestrap et al., 2002) which results in the opening of the mitochondrial permeability transition pore (MPTP) and allows the equilibration of small solutes and the release of pro-apoptotic proteins from the intermembrane space

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Vitamin D at high doses interacts with thiazide diuretics, heart rhythm drugs (verapamil, diltiazem, digoxin), and several other medications

Panels A, B, and C show the percentage of surviving hepatocytes for females (blue curves) and males (red curves) for a 15 g dose, an 18 g dose of APAP, and a 30 g dose of APAP, respectively, over the first 80 h after ingestion