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J Inherit Metab Dis 2017;40:21-48

Age-Related Changes Our natural production of glutathione begins to decline as early as our 20s

In addition, a negative correlation exists between zinc finger transcription factors (Snail, Slug, Twist and ZEB1) and E-cadherin expression

Pretorius et al., 2016)

Taken together, these findings position AKT1 not only as a molecular hallmark of advanced lipedema but also as a promising therapeutic target that warrants further validation in preclinical models and pharmacological intervention studies