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Furthermore, the immunological consequences of these hybrid systems are gaining attention, with evidence suggesting that AuNP-resveratrol complexes modulate tumor-associated macrophages (TAMs) and enhance T-cell infiltration, potentially converting immunologically cold tumors into hot microenvironments responsive to checkpoint inhibitors

thus, expert opinion suggests some level of safety in human subjects may be assumed

62,63 Excess iron is stored in unstable iron pools, which can increase due to metabolic imbalance, leading to increased ROS production through Fenton reactions

Both RNA and ATAC-seq libraries were constructed using Chromium Next GEM Single Cell Multiome ATAC + Gene expression kit (10X Genomics, PN-1000281)

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