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12.6 Pathways of biliverdin production from heme by chain-opening and bilirubin production by reduction of biliverdin (Reproduced with permission from Odell [15]) After its formation in reticuloendothelial cells, bilirubin is released into the bloodstream, where it is transported bound to albumin via one primary and two secondary binding sites

Activation of nuclear factor B in colonic mucosa from patients with collagenous and ulcerative colitis

Monoclonal antibodies (anti-tumor necrosis factor [TNF] agents, vedolizumab) are the last pharmacotherapeutic option for UC patients before surgery becomes inevitable

Naltrexone : Blocks the effects of opioids and may be used to induce withdrawal

10.1016/j.autrev.2020.102645 163 WysockiT.OlesiskaM.Paradowska-GoryckaA