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By analyzing the aortic tissue, we found that FOXO4-DRI treatment significantly increased the expression levels of Ki-67 and Lamin B, while reducing the expression of P21, P16, and -H2AX, similar to the results obtained from naturally aged mice (Figure 2A)

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In practice, studies dissolve the peptide in sterile water or buffered media and apply it at tiny concentrations, usually somewhere between a billionth and a millionth of a mole per liter

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