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We further underscore the physiological importance of the PHD2-HIF-axis by showing that HIF-1 promotes glycogen synthesis and initiates a metabolic shift to glycolytic energy production by increasing glucose uptake, glycolytic flux, pyruvate-to-lactate flux and lactate secretion in astrocytes and neurons (Figure 9) resulting in improved intrinsic tolerance to ischemia

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Post-sacrifice assessment would eliminate as prime cause the muscular weakness, joint distension or joint stiffness, and pain, leg contracture, present (controls) or absent (BPC 157-rats), reflects the posture phenotype related to the continued disconnection or recovered connection of the muscle-tendon unit

Sweeten TL, Posey DJ, Shankar S, McDougle CJ

Oral supplements must pass through your digestive system where absorption is inconsistent especially in people over 50 or those with digestive issues