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Confocal images were acquired with 405 nm laser/418495 nm filter and 488 nm laser/499615 nm filter

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The liver, which houses the highest glutathione concentrations and performs extensive detoxification work during sleep, may benefit from elevated glutathione availability during these nighttime processes

In Pgam5 -deleted mice, it counterproductively promoted mitochondrial fusion, leading to intracellular ROS accumulation as well as oxidative stress, thus accelerating RPE cell senescence, in which the IRF/IFN- pathway was also observed, which may be related to cell senescence