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Leukocyte adhesion accelerates the loss of endothelial cells and disrupts the blood-retinal barrier by releasing inflammatory cytokines, growth cytokines and vascular permeability factors ( Interccellular adhesion molecule 1 (ICAM-1), which is increased in disorders such uveitis, diabetes, and age-related macular degeneration, is crucial for the migration of white blood cells ( Vascular cell adhesion molecule-1 (VCAM-1), which binds to integrin, is expressed on endothelial cells ( Elevated levels of selectin induce the aggregation of leukocytes into the endothelial wall and then lead to retinal leukostasis

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