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Systematic review registration: CRD420251161230, identifier CRD420251161230

A larger study (SEMA-NASH) enrolling 320 individuals with obesity, biopsy-proven NASH and different degrees of fibrosis, with or without diabetes, demonstrated that OD subcutaneous semaglutide 0.4 mg significantly resolved MASH without worsening fibrosis in 59% of patients 93

Unlike traditional weight loss medications that often target a single pathway, cagrilintide acts as a dual agonist, primarily affecting both the amylin receptor and, in some cases, the calcitonin receptor

CagriSema is investigational under FDA review with a decision expected in 2026, not yet approved [4]

The following parameters (Figure 1) have been adapted with modifications from FIGURE 1 Baseline Phase During the pre-intervention days, mice were given free access to all cage areas for 4 days without receiving any drug intervention