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This translocation of the luminal contents into the lamina propria persistently stimulates the immune system leading to its hyper-activation and eventual damage to the intestine

It requires sterile technique, causes discomfort for needle-averse individuals, creates potential injection site reactions, and demands careful rotation to avoid tissue damage over extended protocols

PYY(3-36) and exendin-4 reduce food intake and activate neuronal circuits in a synergistic manner in mice

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