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Polymeric nanoparticles, such as those generated from polylactic-co-glycolic acid (PLGA) or polyethylenimine (PEI), also appear promising, as these materials can be tailored to deliver siRNA precisely to microglia or neurons while allowing for prolonged release (96)

Peptides are short chains of amino acids the same building blocks proteins are made from

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Firstly, the permeability of EBA increased after 24-h incubation with 3-PLG-ibu, and secondly, in inflammatory condition besides the 3-PLG-ibu-A-GSH the free ibuprofen treated group also significantly strengthened the integrity of the BBB model for the bigger transcellular marker molecule (Fig

Molecular characterization and tissue distribution of ZO-2, a tight junction protein homologous to ZO-1 and the Drosophila discs-large tumor suppressor protein