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The data of regular yearly follow-up, including auxological and hormonal data, were recorded (Table 1 and Fig

An eight-week clinical study showed that patients treated with 500 mg of buccal glutathione lozenge had a significant reduction in melanin index [95], while patients treated with topical glutathione (2%) suspension also showed efficacy [96]

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Methylation connects with glutathione through homocysteine and the transsulfuration pathway, which can provide cysteine for glutathione synthesis

However, CPZ demyelination more faithfully recapitulates the human DAO transcriptional program, particularly the downregulation of myelin and homeostatic genes