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Social determinants of health were measured at the county-level using the SVI (high SVI=greater social vulnerability) developed by the CDC

Ren Y, Liu Y, Yang Z, Niu R, Gao K, Yang B, et al

and downregulates PI3K/Akt and mTOR pathway [125, 126], involved in regulating a variety of processes including insulin signaling, cell proliferation, and survival [127]