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BBR has also been shown to improve lipid metabolism and reduce oxidative stress and hepatic steatosis by activating the AMPK/SIRT1 signaling pathway ( 6.8 BBR ameliorates diabetic pulmonary injury BBR, as the main active component of Coptis chinensis inflorescence extract, reduces the expression of inflammatory cytokines by activating the AMPK/NEU1 pathway and inhibiting the TGF1/Smad pathway, reverses EMT and reduces pathological damage in lung tissue (Wang et al., 2023)

If the ARA MW score biomarker is required for a PSA 50 response to BAT, and the PSA 50 response rate among biomarker-positive patients is 70%, then the predicted PSA response rate to BAT among patients with mCRPC is 25.6% (i.e., 36.5% 70%)

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Structural Insights from a DNA-bound Complex of Full-length Androgen Receptor A major development in our understanding of AR mechanism of action has been the recent description of the structure of the full-length receptor bound to DNA and co-regulatory proteins (SRC-3 and p300) (164)