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AOD9604 represents part of a broader scientific effort to develop targeted therapies that can isolate beneficial effects of growth hormone while avoiding unwanted systemic effects, similar to the development of selective androgen receptor modulators (SARMs) or selective estrogen receptor modulators (SERMs) in other therapeutic areas

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Direct protection is offered by antioxidants: glutathione (GSH), ascorbate (vita-min C), tocopherol (vitamin E), and carotinoids

DOI: 10.1016/j.bbagen.2012.09.018 26