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While the efficacy data did not survive the Phase IIb primary endpoint, the safety dataset across 900 participants is unusual for a research peptide and is consistently cited as the basis for continued investigational interest

As mentioned above, loading potentiometric dyes into live cells requires optimization and careful consideration of loading conditions

Adems de las manifestaciones dermatolgicas diagnsticas de la NF1 (MCCL, eflides y neurofibromas), existen otras alteraciones cutneas como los nevus anmicos y los xantogranulomas juveniles, cuya presencia parece ser de gran valor predictivo en los pacientes sin diagnstico de certeza

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The funding body has no role in the study design and analysis