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Peer review Peer review information Communications Biology thanks Stephan Klaehn, Katja Bhler and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

It has been suggested that several food and lifestyle choices contribute to the onset of cancer, presumably via complex metabolic and inflammatory pathways

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The mechanism is purely metabolic: increased energy expenditure , suppressed lipogenesis, and elevated NAD+ levels that activate sirtuins (SIRT1, SIRT3), the same longevity-associated enzymes targeted by caloric restriction