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4e, PCA analysis indicated that principal component 1 (PC1) covered most of the variation in gene expression (58% of total variance), likely including the effect caused by Gclc deletion

While TMT-induced neurotoxicity and cognitive impairments in animal models can provide insights into certain aspects of neurodegeneration and memory deficits, AD is a complex and multifactorial disease with genetic, environmental, and age-related factors playing significant roles

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At the same time, activated platelets release mediators such as P-selectin and TGF-, which intensify local inflammation, promote microthrombosis, and stimulate fibroblast proliferation

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