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10.3390/nu9050451 Nutrients 28 NegiS.KhuranaN.DuggalN

To date, genetic research has identified over 100 genetic loci associated with IBD susceptibility, many of which regulate the hosts immune response to bacteria, such as NOD2, TLR5, and IL-10

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However, tumor cells can also exploit the oxidative stress-ERS interplay to develop resistancefor example, by activating the ER chaperone protein GRP78 to repair misfolded proteins while enhancing the antioxidant defense system to reduce ROS levels and diminish therapeutic efficacy [86]