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Conversely, it has been shown that increased NCOA4 by knockdown of COPZ1 (coatomer protein complex subunit zeta 1) results in the degradation of ferritin and induction of ferroptosis in GBM [132]

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PDK activity is inhibited by allosteric regulation from pyruvate, which typically accumulates because of PDHC inhibition by PDKs

[DOI] [PMC free article] [PubMed] [Google Scholar] 15.American College of Obstetricians and Gynecologists (ACOG) ACOG response to consensus statement on paracetamol use during pregnancy