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An alternative approach to diagnosis is to wait until the hemolytic crisis is over and reevaluate the patient after the red blood cell mass is repopulated with cells of all ages (approximately 2 to 3 months)

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The two-cysteine peroxiredoxin catalytic mechanism revolves around oxidation of the active site (peroxidatic) cysteine that is subsequently attacked by the resolving cysteine on the other subunit, forming a disulphide bond

2 and supplementary information for Extended Data Fig