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Tsuji J, Li T, Grinshpun A, Coorens T, Russo D, Anderson L, et al

It is not clear if these changes are independent of cortical pathology or the cortical structural damages are beyond the detection limits of methods at early stages of the disease [29, 30, 40] and subtle neurodegenerative changes could precede or promote white matter changes even if they are not detectable with conventional methods

Results depend on the protocol, nutrition, exercise, sleep, and medical factors

PubMed Simon, J.A., Kingsberg, S.A., Portman, D.J., Lucas, J., Jordan, R., Clayton, A.H., & Shifren, J.L